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. 2021 Jul 9;12(7):691. doi: 10.1038/s41419-021-03973-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Analysis of WDR4 transcript levels in HCC and normal tissues based on the TCGA database. B Overall and relapse-free survival curves of HCC patients. C WDR4 transcript levels are significantly related to HCC tumour stage and grade. D WDR4 expression in immortalized hepatocytes and six HCC cells. E, F Representative WDR4 expression and IHC results in 80 pairs of tumour tissues. *p < 0.05; **p < 0.01; ***p < 0.001.