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. 2021 Jul 9;12(7):691. doi: 10.1038/s41419-021-03973-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A After WDR4 knockdown, a scratch wound-healing motility assay was used to assess cell migration. B Transwell Matrigel invasion assay to measure the cell invasion ability. C qRT-PCR and Western blot results showed changes in EMT. D WDR4 knockdown in HCC-LM3, HCC-LM3^R, Huh-7, and Huh-7^R cells increases their sensitivity to sorafenib. E CCK-8 assay results showing the proliferation ability of HCC-LM3, HCC-LM3^R, Huh-7, and Huh-7^R cells. *p < 0.05; **p < 0.01; ***p < 0.001.