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. 2021 Jul 9;12(7):691. doi: 10.1038/s41419-021-03973-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Multidatabase joint analysis predicts MYC as a transcription factor of WDR4. B Pearson correlation analysis of WDR4 and MYC in the TCGA-LIHC dataset and HCC tissue samples. C After MYC knockdown, WDR4 mRNA and protein levels were significantly reduced. D MYC expression in different cell lines. E MYC binding sites in the wild-type (WT) and mutant (MUT) WDR4 promoters. Dual-luciferase reporter assays showing that MYC acts on the WDR4 promoter region. F ChIP results show that MYC binds to WDR4 (primers 1−2 are different primers for the WDR4 promoter). G CCK-8 assay results showing the proliferation ability of Huh-7 and HCC-LM3 cells. *p < 0.05; **p < 0.01; ***p < 0.001.