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. 2021 Jul 9;11:14248. doi: 10.1038/s41598-021-93756-x

Table 2.

Robust and reproducible features across all sequences.

Features Shape maximum 3D diameter Shape major axis length Shape elongation Shape maximum 2D diameter slice Shape minoraxis length Shape maximum 2D diameter column Shape maximum 2D diameter row glcm Imc1
T2w TSE CCC 1.00 0.99 0.96 1.00 0.99 1.00 1.00 0.99
DR 0.98 0.98 0.95 0.99 0.96 0.98 0.98 0.97
Intra-observer ICC 1.00 0.99 1.00 1.00 0.99 1.00 1.00 1.00
Inter-observer ICC 0.99 1.00 1.00 1.00 1.00 0.99 0.99 0.99
T1w TSE CCC 1.00 0.98 0.99 1.00 0.98 1.00 0.99 0.93
DR 0.97 0.95 0.95 0.98 0.96 0.97 0.97 0.91
Intra-observer ICC 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
Inter-observer ICC 0.99 0.99 0.99 1.00 0.99 0.98 0.98 0.97
FLAIR CCC 1.00 1.00 0.98 1.00 0.99 1.00 0.99 0.97
DR 0.97 0.96 0.96 0.99 0.96 0.97 0.95 0.94
Intra-observer ICC 1.00 0.99 0.99 1.00 0.99 1.00 0.99 0.99
Inter-observer ICC 0.98 0.98 0.99 1.00 0.98 0.98 0.97 0.96
T2 map CCC 0.99 1.00 0.92 0.99 0.99 0.99 0.99 1.00
DR 0.96 0.98 0.93 0.98 0.97 0.96 0.95 0.97
Intra-observer ICC 1.00 1.00 0.99 1.00 1.00 0.99 0.99 0.99
Inter-observer ICC 0.99 1.00 0.99 0.99 1.00 0.99 0.98 0.99
HASTE CCC 1.00 0.99 0.93 1.00 0.99 0.99 0.99 0.98
DR 0.98 0.97 0.93 0.99 0.96 0.96 0.97 0.96
Intra-observer ICC 1.00 0.99 0.99 1.00 0.99 0.99 0.99 0.99
Inter-observer ICC 0.99 0.99 0.99 1.00 0.99 0.99 0.99 0.99

Across all sequences, eight features proofed to be robust and reproducible. Except of Imc1 from the GLCM feature class, all other features were shape features. CCC concordance correlation coefficient, DR dynamic range, FLAIR fluid-attenuated inversion recovery, GLCM gray level co-occurrence matrix, HASTE half-Fourier acquisition single-shot turbo spin-echo, ICC intraclass correlation coefficient, T1w T1-weighted, T2w T2-weighted, TSE turbo spin-echo.