Table 2.

Different methods of nanofiber-based scaffold fabrication

Processing Technique	Processability	Fibre diameter	Advantages	Disadvantages
Template synthesis	Easy	Around 100 nm	Fibers with varied diameters can be easily made using suitable template	Difficult to produce long continuous nanofibers
Fiber drawing	Easy	2–100 nm	Minimum equipment requirement	Discontinuous process
Self-assembly	Difficult	Around 100 nm	Suitable for small nanofibers Good control over pore size, percent porosity and fiber diameter	Expensive material Intricate process Complex design parameters
Phase separation	Easy	50–500 nm	Consistent property	Suitable only for selected polymers Difficult to control scaffold morphology
Electrospinning	Easy	3–1000 nm	Continuous process and gives nanofibers of higher L/D ratio Precise control over fiber diameter, percent porosity and pore size	Jet instability