Table 1.

Examples of RNAs identified in EVs, and the RNA role in cancer progression.

RNA species	RNA	Cancer of origin	Pro-tumoral Function	Reference
miRNA	miR-10b	Colorectal	Myofibroblast differentiation	(45)
	miR-1246	Breast	Increased viability, migration	(46)
	miR-25-3p	Liposarcoma	Pro-inflammatory cytokine production	(47)
	miR-222	Pancreatic ductal adenocarcinoma	Proliferation	(48)
	miR-93-5p	Esophageal	Proliferation	(50)
	miR-1249-5p	Colorectal	Proliferation	(51)
	miR-93	Hepatocellular carcinoma	Metastasis	(52)
	miR-99a-5p	Ovarian	Invasion, fibronectin and vitronectin upregulation	(53)
	miR-105	Breast	Vascular leakiness	(54)
	miR-103	Liver	Vascular leakiness	(55)
	miR-24-3p	Nasopharyngeal carcinoma	Downregulate T-cell proliferation	(77)
	miR-203	Pancreatic	Dendritic cell dysfunction	(78)
	miR-21	Ovarian	Apoptotic escape	(80)
	miR-122	Breast	Metabolic reprogramming	(83)
IncRNA	MALAT1	Breast	Migration	(58)
	HOTAIR	Bladder	Epithelial-mesenchymal transition	(60)
	ZFAS1	Gastric	Cell cycle regulation	(61)
	RPPH1	Colorectal	Macrophage polarisation	(62)
	lncRNA91H	Colorectal	Migration	(63)
	ZEB1-AS1	Esophageal	Proliferation	(64)
	Linc-CCAT2	Glioma	Angiogenesis	(70)
	POU3F3	Glioma	Angiogenesis	(71)
	lncH19	Liver	Angiogenesis	(72)
	TUC339	Hepatocellular carcinoma	Pro-inflammatory cytokine production	(76)
	PVT1	Colon	Apoptotic escape	(81)
	lncARSR	Renal carcinoma	Therapy resistance	(90)
mRNA	hTERT	T-cell leukaemia	Inhibition of fibroblast senescence	(68)
	MMP1	Ovarian	Apoptosis of mesothelial cells	(86)