Table 5.

Direct and indirect effects (through age at menarche) of trauma, abuse, and neglect on PhenoAge acceleration, accounting for cell counts (CD8naive, CD8pCD28nCD45Ran).

Predictor	Outcome	b	SE	ß	p	95% CI
Trauma	Age Acceleration	0.05	0.05	.07	.33	[−0.05, 0.13]
Menarche	Age Acceleration	−0.22	0.27	−.07	.42	[−0.75, 0.31]
CD8naive	Age Acceleration	−0.04	0.01	−.37	<.001	[−0.07, −0.02]
CD8pCD28nCD45Ran	Age Acceleration	0.01	0.01	.09	.36	[−0.01, 0.03]
Trauma	Menarche	−0.02	0.02	−.08	.45	[−0.06, 0.02]
CD8naive	Menarche	−0.01	<.01	−.14	.24	[−0.01, <.01]
CD8pCD28nCD45Ran	Menarche	<.01	<.01	−.11	.36	[−0.01, <.01]
Indirect Effect through Menarche		<0.01	0.01	.01	.57	[−0.01, 0.02]
Abuse	Age Acceleration	0.05	0.06	.06	.41	[−0.06, 0.15]
Menarche	Age Acceleration	−0.21	0.27	−.06	.44	[−0.74, 0.32]
CD8naive	Age Acceleration	−0.04	0.01	−.36	<.001	[−0.06, −0.02]
CD8pCD28nCD45Ran	Age Acceleration	0.01	0.01	.10	.32	[−0.01, 0.03]
Abuse	Age Acceleration	−0.03	0.02	−.11	.30	[−0.07, 0.02]
CD8naive	Menarche	−0.01	<.01	−.13	.26	[−0.01, <.01]
CD8pCD28nCD45Ran	Menarche	<.01	<.01	−.10	.39	[−0.01, <.01]
Indirect Effect through Menarche		0.01	0.01	0.01	.52	[−0.01, 0.02]
Neglect	Age Acceleration	0.16	0.16	.06	.32	[−0.15, 0.47]
Menarche	Age Acceleration	−0.23	0.26	−.07	.38	[−0.74, 0.28]
CD8naive	Age Acceleration	−0.05	0.01	−.38	<.001	[−0.07, −0.02]
CD8pCD28nCD45Ran	Age Acceleration	0.01	0.01	.08	.42	[−0.01, 0.03]
Neglect	Menarche	0.03	0.07	.05	.61	[−0.10, 0.17]
CD8naive	Menarche	−0.01	<.01	−.18	.12	[−0.01, <.01]
CD8pCD28nCD45Ran	Menarche	<.01	<.01	−.13	.27	[−0.01, <.01]
Indirect Effect through Menarche		−0.01	0.02	<0.01	.66	[−0.04, 0.03]