Table 6.

Direct and indirect effects (through age at menarche) of trauma, abuse, and neglect on

DNAm GrimAge acceleration, accounting for cell counts (CD8naive, CD8pCD28nCD45Ran).

Predictor	Outcome	b	SE	ß	p	95% CI
Trauma	Age Acceleration	0.08	0.03	.23	.003	[0.03, 0.13]
Menarche	Age Acceleration	−0.45	0.13	−.26	.005	[−0.71, −0.19]
CD8naive	Age Acceleration	−0.02	0.01	−.26	.006	[−0.03, −0.01]
CD8pCD28nCD45Ran	Age Acceleration	0.01	0.01	.19	.04	[<.01, 0.02]
Trauma	Menarche	−0.02	0.02	−.08	.45	[−0.06, 0.02]
CD8naive	Menarche	−0.01	<.01	−.14	.23	[−0.01, <.01]
CD8pCD28nCD45Ran	Menarche	<.01	<.01	−.11	.36	[−0.01, <.01]
Indirect Effect through Menarche		0.01	0.01	.02	.48	[−0.01, 0.03]
Abuse	Age Acceleration	0.09	0.03	.23	.004	[0.03, 0.15]
Menarche	Age Acceleration	−0.44	0.13	−.24	.001	[−0.70, −0.18]
CD8naive	Age Acceleration	−0.02	0.01	−.26	.004	[−0.03, −0.01]
CD8pCD28nCD45Ran	Age Acceleration	0.01	0.01	.19	.04	[<.01, 0.02]
Abuse	Age Acceleration	−0.03	0.02	−.11	.30	[−0.07, 0.02]
CD8naive	Menarche	−0.01	<.01	−.13	.26	[−0.01, <.01]
CD8pCD28nCD45Ran	Menarche	<.01	<.01	−.10	.39	[−0.01, <.01]
Indirect Effect through Menarche		0.01	0.01	0.03	.35	[−0.01, 0.03]
Neglect	Age Acceleration	0.19	0.10	.15	.05	[<.01, 0.38]
Menarche	Age Acceleration	−0.47	0.14	−.26	.001	[−0.74, −0.19]
CD8naive	Age Acceleration	−0.02	0.01	−.25	.01	[−0.03, <.01]
CD8pCD28nCD45Ran	Age Acceleration	0.01	0.01	.19	.05	[<.01, 0.02]
Neglect	Menarche	0.03	0.07	.05	.61	[−0.10, 0.17]
CD8naive	Menarche	−0.01	<.01	−.18	.12	[−0.01, <.01]
CD8pCD28nCD45Ran	Menarche	<.01	<.01	−.13	.27	[−0.01, <.01]
Indirect Effect through Menarche		−0.02	0.03	−0.01	.60	[−0.08, 0.04]