Figure 2.

Heatmap of differential expression (DE) genes in YMA vs AMA and IMA vs AMA comparisons

(A) Samples ordered by chronological maternal age (YMA cohort = yellow, IMA cohort = green, AMA cohort = blue).

(B) Samples ordered by biological maternal reproductive age (rba-YMA cohort = yellow, rba-IMA cohort = green, rba-AMA cohort = blue) and samples that were called as ‘unclassified’ (gray) due to their unique gene expression patterns. Black arrows indicate samples that behave more like the AMA samples and gray arrows indicate samples that behave like the YMA samples. Red arrows illustrate samples that become part of the ‘unclassified’ group when considered by biological reproductive age. Gene expression levels are illustrated as Z-scores (blue to red). The black bars to the right of the heatmaps indicate 632 gene names, which are too densely packed to be legible here. The full list is available in Tables S1 and S2.