Table 2.

Associations of Z-score hs-CRP, fibrinogen, and D-dimer with macrovascular dysfunction in the whole cohort.

	Aortic stiffness		Coronary artery disease		Peripheral artery disease
	OR (95% CI), p-value		OR (95% CI), p-value		OR (95% CI), p-value
	Model 1	Model 2	Model 1	Model 2	Model 1	Model 2
hs-CRP	1.25 (1.15–1.36), <0.001	1.05 (0.94–1.16), 0.372	1.21 (1.13–1.29), <0.001	1.15 (1.07–1.24), <0.001	1.16 (1.07–1.26), 0.001	1.04 (0.95–1.15), 0.373
Fibrinogen	1.58 (1.44–1.73), <0.001	1.04 (0.93–1.16), 0.502	1.18 (1.10–1.27), <0.001	1.09 (1.01–1.19), 0.034	1.12 (1.02–1.23), 0.016	1.01 (0.91–1.12), 0.891
D-Dimer	1.15 (1.07–1.23), <0.001	0.99 (0.92–1.08), 0.881	1.05 (0.98–1.11), 0.174	1.02 (0.95–1.09), 0.666	1.07 (1.00–1.15), 0.047	1.05 (0.97–1.13), 0.235

Abbreviations: CI = confidence interval, hs-CRP = high sensitivity C-reactive protein, OR =odds ratio.

Model 1: unadjusted; Model 2: fully adjusted i.e. adjusted for age, sex; smoking (pack-years), BMI, hypertension, HbA1c, total cholesterol, and use of statins.