Table 1.

Analysis of inter-protein co-evolution utilizing Co-Var and other existing methodologies. Statistics for student’s t-test performed utilizing co-evolution parameters obtained for interacting (positive) and non-interacting (negative) proteins in Co-Var, MirrorTree, CAPS and EV-complex has been outlined here.

	Co-Var		MirrorTree correlation coefficient		CAPS		EV-complex
	Positive (n = 50)	Negative (n = 50)	Positive (n = 50)	Negative (n = 50)	Positive (n = 50)	Negative (n = 50)	Positive (n = 50)	Negative (n = 50)
Mean	7.73	1.26	0.84	0.42	0.01	0.04	7.275	0.729
Standard deviation	2.71	0.75	0.12	0.34	0.019	0.1	6.034	2.5
T-test statistics	t = 16.2703 df = 98		t = 8.2369 df = 98		t = 2.0840 df = 98		t = 6.8875 df = 96
P-value	<= 0.0001		<= 0.0001		0.0398		<=0.0001