Table 2.
Co-evolution analysis in hetero-dimeric protein complexes involved in inter-cellular interactions. Co-evolutionary pairings were identified utilizing Co-Var and a z-score threshold of z <= −1 to study co-evolution in inter-cellular protein interaction complexes.
| Reference PDB structure | Reference sequence (Family A) | Reference sequence (Family B) | aPC | bIC | |
|---|---|---|---|---|---|
| Case 1 | 2D9Q | CSF3 (P09919) | CSF3R (Q99062) | 16.883 | 0.184 |
| Case 2 | 1MOX | EGFR (P00533) | TGFA (P01135) | 2.203 | 0.161 |
| Case 3 | 1EVT | FGF1 (P05230) | FGFR1 (P11362) | 3.185 | 0.15 |
| Case 4 | 1KTZ | TGFB3 (P10600) | TGFBR2 (P37173) | 5.66 | 0.053 |
| Case 5 | 1NUN | FGF10 (O15520) | FGFR2 (P21802) | 1.429 | 0.125 |
| Case 6 | 1DJS | FGF1 (P05230) | FGFR2 (P21802) | 4 | 0.374 |
a
PC: Percentage of interface pairs that are predicted to be co-evolved.
b
IC: Percentage of co-evolved pairs that occur at the interface.