Table 4.
Intra-protein co-evolving positions in proteins constituting a complex are also predicted as high degree inter-protein co-evolved positions. Inter-protein co-evolving residue positions that have large number of co-evolutionary connections (high degree) between proteins are likely to be important for intra-molecular co-evolution as well.
| Reference sequence (Protein family A) | Reference sequence (Protein family B) | aIntra-protein CP (A) | bIntra-protein CP (B) | cInter-protein CP (A) | dInter-protein CP (B) | eInter-protein and intra-protein CP (A) | fInter-protein and intra-protein CP (B) | |
|---|---|---|---|---|---|---|---|---|
| Case 1 | CSF3 (P09919) | CSF3R (Q99062) | 79 | 272 | 68 | 187 | 58 | 67 |
| Case 2 | EGFR (P00533) | TGFA (P01135) | 120 | 40 | 251 | 23 | 37 | 13 |
| Case 3 | FGF1 (P05230) | FGFR1 (P11362) | 56 | 166 | 36 | 143 | 34 | 23 |
| Case 4 | TGFB3 (P10600) | TGFBR2 (P37173) | 116 | 161 | 104 | 95 | 53 | 45 |
| Case 5 | FGF10 (O15520) | FGFR2 (P21802) | 85 | 107 | 42 | 88 | 34 | 28 |
| Case 6 | FGF1 (P05230) | FGFR2 (P21802) | 55 | 171 | 33 | 101 | 28 | 21 |
Intra-protein CP (A): Number of residue positions involved in intra-protein co-evolutionary pairings in reference protein of family A.
Intra-protein CP (B): Number of residue positions involved in intra-protein co-evolutionary pairings in reference protein of family B.
Inter-protein CP (A): Number of residue positions involved in inter-protein co-evolutionary pairings in reference protein of family A.
Inter-protein CP (B): Number of residue positions involved in inter-protein co-evolutionary pairings in reference protein of family B.
Inter-protein and intra-protein CP (A): Number of residue positions important for inter-protein (high degree) and intra-protein co-evolution (Protein A).
Inter-protein and intra-protein CP (B): Number of residue positions important for inter-protein (high degree) and intra-protein co-evolution (Protein B).