Table 2.
MR results assessing causal effects of insomnia on specific pain category cohorts within FinnGen R5
| Pain type | Cases | Controls | OR [95% CI] | P | Bonferroni P |
|---|---|---|---|---|---|
| Abdominal and pelvic area pain | 49,416 | 161,968 | 1.40 [1.30–1.52] | 8.30 × 10−18 | 4.98 × 10−17 |
| Joint pain | 13,419 | 131,550 | 1.62 [1.44–1.82] | 1.65 × 10−15 | 9.9 × 10−14 |
| Limb pain | 12,606 | 167,641 | 1.48 [1.31–1.66] | 6 × 10−11 | 3.6 × 10−10 |
| Low back pain | 13,178 | 164,682 | 1.70 [1.50–1.93] | 1.46 × 10−16 | 8.76 × 10−16 |
| Ocular pain | 893 | 216,919 | 1.77 [1.22–2.57] | 0.003 | 0.018 |
| Throat and chest pain | 24,609 | 163,123 | 1.37 [1.24–1.51] | 5.58 × 10−10 | 3.35 × 10−9 |
Exposure instruments for insomnia from Jansen et. al, Bonferroni corrected p (accounting for six pain types) threshold = 0.05 (corresponding to 0.0083 nominal p).