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Oncolytic viruses. Many OVs selectively replicate in cancer cells (cellular tropism) and lyse the cells. The resultant release of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) recruits and activates dendritic cells (DCs). DCs then migrate to lymph nodes and present the antigens to the T cells. These activated cytotoxic T cells undergo clonal expansion. They induce apoptosis in target cells via the release of perforin and granzymes.
