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. 2020 Oct 23;50(3):1011–1015. doi: 10.1093/ije/dyaa148

Table 2.

Interpretation of the coefficients in Equation 1 and Equation 2 along with the relationships between the coefficeints of the two models

Equation 1 Equation 2 Relationships
Baseline level: E(Yt|T = 0) β0 β′0 β0 = β′0

Pre-intervention slope:

E(Yt+1 − Yt | T ≤ Ti)

0 + β1(T+1)] − (β0 + β1T)

= β1

[β′0 + β′1(T + 1)] − (β′0 + β′1T)

= β′1

β1 = β′1

Post-intervention slope:

E(Yt+1 − Yt | T>Ti)

01(T+1)+β23(T + 1 − Ti)]

− [β01T+β23(T − Ti)]

= β13

[β′0 +β′1 (T + 1) + β′2 + β′3 (T + 1 − Ti)] − [β′0 +β′1 T + β′2 + β′3 (T − Ti)]

= β′1+β′3

β3 = β′3

Slope change:

E(Yt+1 − Yt | T>Ti) –

E(Yt+1 − Yt | T≤Ti)

13) − β1

= β3

(β′1+β′3) − β′1

= β′3

Immediate/level change:

E(Yt |T = Ti & Xt = 1 ) −

E(Yt | T=Ti & Xt = 0)

01T+(β23Ti)]-[β01T]

= β23Ti

(β′0 + β′1T + β′2) − [β′0 + β′1T]

= β′2

β2 + β3Ti = β′2

Where Yt is the outcome at time t, T is the time elapsed since the start of the study, Xt is a dummy variable indicating the pre-intervention period (coded 0) or the post-intervention period (coded 1). Ti represents the time point when the intervention starts (Xt = 1 for T ≥ Ti). β0 or β′0 represents the baseline level of Y at T = 0, β1 or β′1 represents the underlying pre-intervention trend (the change in Y associated with a single-unit increase in time before the intervention), (β2 + β3Ti) or β′2 both purport in the peer-reviewed literature to represent the immediate level (or intercept) change following the intervention, and β3 or β′3 is interpreted as the change in the slope of the trend following the intervention, compared with the pre-intervention trend