Table 1.

Diagnostic characteristics of Mayo Clinic and case-reported patients with coexisting pheochromocytoma and primary aldosteronism

Patient number	Sex	Age (years)	Symptoms of catecholamine excessa	Initial blood pressure (mm Hg)	Hypokalemiab present	PACc (ng/dL)	PRAd (ng/mL/h)	Urinary aldosteronee (mcg/24 h)	Biochemical phenotype of PHEO	Tumor size(s) on imaging (mm)	Site of aldosterone excess on adrenal vein sampling
1	Male	59	Yes	142/86	Yes	45	0.6	35	Adrenergic, Dopaminergic	Right: 30	Bilateral
2	Male	68	No	170/90	Yes	29	0.6	31	Adrenergic	Right: 33	Not performed
3 [22]	Male	63	Yes	160/94	Yes	22	0.7	29.2	Adrenergic	Right: 40	Bilateral
										Left: 12
4	Male	62	Yes	160/75	Yes	18	0.6	40	Noradrenergic	Right: 10	Bilateral
										Left: 12
5	Female	62	Yes	124/84	Yes	11	0.6	84	Noradrenergic	Right: 31	Not performed
										Left: 44
6 [5]	Male	49	No	150/110	Yes	28.5	0.21	Unknown	Functioning, phenotype unclear	No imaging	Left
7 [6]	Male	46	No	180/100	Yes	20	0.13	Unknown	Noradrenergic	Right: unknown	Not performed
8 [7]	Female	40	No	“Mildly hypertensive”	Yes	21.4	0.3	Unknown	Adrenergic	Right: 40	Bilateral (left dominant)
9 [7]	Female	63	Yes	“Normo-tensive”	No	Unknown	Unknown	Unknown	Adrenergic	Left: 50	Not performed
10 [8]	Female	39	No	142/95	Yes	64	0.2	Unknown	Unknown	Right: 15	Not performed
11 [9]	Male	49	No	162/96	Yes	117.1	0.1	39.2	Noradrenergic	Right: 40	Left
										Left: 10
12 [10]	Male	57	No	210/120	Yes	42	0.004	Unknown	Adrenergic	Right: 70	Left
										Left: 10
13 [11]	Female	40	No	152/92	Yes	20	0.1	Unknown	Noradrenergic, dopaminergic	Left: 25	Left
14 [12]	Female	36	No	202/120	Yes	40.7	1.2	19	Noradrenergic	Right: unknown	Bilateral
										Left: unknown
15 [13]	Female	53	Yes	150/100	No	33.4	0.005	Unknown	Adrenergic	Right: 30	Not performed
										Left: 20, 7

Abbreviations: PAC, plasma aldosterone concentration; PHEO, pheochromocytoma; PRA, plasma renin activity.

^aSymptoms of catecholamine excess were defined as headaches, palpitations, diaphoresis, and/or anxiety spells.

^bHypokalemia was defined as K <3.5 mEq/L and/or requiring potassium supplementation or mineralocorticoid receptor blockade.

^cPAC normal range <10 ng/dL;

^dPRA normal range <1 ng/mL/h;

^eNormal range of urinary aldosterone concentration was <12 mcg/24 h.