Table 2.

Classification for [¹⁸F]FDG findings suggested by the EANM Procedural recommendations for PET/CT imaging of CS

Modified from [110]

[18F]FDG PET/CT finding	Perfusion finding (SPECT or PET)	CMR findings	Final interpretation
No [18F]FDG uptake	Normal	No LGE	No CS (< 10%)
Diffused [18F]FDG uptake (homogeneous)	Normal	No LGE	Uptake most likely due to suboptimal patient preparation
Isolated lateral wall [18F]FDG uptake	Normal	No LGE	Uptake possibly related to a normal variant
No [18F]FDG uptake	Small perfusion defect	One focal area of LGE (alternative diagnosis are most likely)	Possible CS (50–90%)
Focal area of [18F]FDG uptake	Normal
No [18F]FDG uptake	Multiple non-contiguous areas of perfusion defect	Typical LGE	Probable CS (50–90%)
Focal or focal on diffused[18F]FDG uptake	Resting perfusion defect
Focal area of [18F]FDG uptake + extracardiac findings	Normal	Typical LGE	Active cardiac sarcoidosis (> 90%)
Focal on diffused[18F]FDG uptake	Perfusion defect	Typical LGE	Active inflammation with scar in the same location with either diffused inflammation or suboptimal preparation
Focal area of [18F]FDG uptake in an area of normal perfusion	Perfusion defect	Typical LGE	Presence of both inactive scar and inflammation in different segments of the myocardium or inactive scar and false-positive physiological [18F]FDG uptake

LGE late gadolinium enhancement