FIGURE 1.

Differentially Expressed Genes (DEGs) across the life course in the heart. (a) PCA plot: juvenile (fJuvenile‐ female juvenile; mJuvenile‐ male juvenile), adult (fAdult‐ female adult; mAdult – male adult), and aged (fAged‐ female aged, mAged‐ male aged); (b) Venn diagram for DEGs in male age comparisons (FDR 5%): Juv‐Adult, adult compared to juvenile as a baseline; Juv‐Aged, aged compared to juvenile as a baseline; adult‐aged, aged compared to adult as a baseline; (c) Venn diagram for DEGs in female age comparisons (FDR 5%): Juv‐Adult, adult compared to juvenile as a baseline; Juv‐Aged, aged compared to juvenile as a baseline; adult‐aged, aged compared to adult as a baseline; (d) Bar graph for up‐ and downregulated DEGs; Juv‐Ad, DEGs from the comparison of adult to juvenile as a baseline; Juv‐Aged, DEGs from aged compared to juvenile as a baseline; Ad‐Aged, DEGs from aged compared to adult as a baseline. (e) Heatmap of 38 overlapping DEGs in females. n = 3 per group; false discovery rate (FDR) <0.05