FIGURE 7.

Differentially Expressed Proteins (DEP) in male plasma across the life course. (a) PCA plot for male age: juvenile (mJuvenile‐ male juvenile), adult (mAdult – male adult), and aged (mAged‐ male aged); (b) Venn diagram for differentially expressed proteins in males (FDR 5%): Juv‐Adult, adult compared to juvenile as a baseline; Juv‐Aged, aged compared to juvenile as a baseline; adult‐aged, aged compared to adult as a baseline; (c) Bar graph for up‐ and downregulated DEPs; Juv‐Ad, DEPs from adult compared to juvenile as a baseline; Juv‐Aged, DEPs from aged compared to juvenile as a baseline; Ad‐Aged, DEPs from aged compared to adult as a baseline. (d) Diagram of overlapping pathways from top 10 enriched pathways from proteomic and transcriptomic analyses for Juv‐Ad and Juv‐Aged comparisons. n = 3 per group; FDR < 0.05