TABLE 1.
Gene Ontology Enrichment Analysis for DEGs across the life course by sex (FDR 5%)
| Males | Females | |||||||
|---|---|---|---|---|---|---|---|---|
| Enrichment FDR | Genes in list | Total genes | Functional Category | Enrichment FDR | Genes in list | Total genes | Functional Category | |
| Juvenile‐Adult | 1.40E‐10 | 13 | 90 | Protein digestion and absorption | 7.00E‐09 | 36 | 119 | Carbon metabolism |
| 2.70E‐06 | 9 | 83 | ECM‐receptor interaction | 4.60E‐07 | 21 | 55 | Valine, leucine and isoleucine degradation | |
| 7.60E‐06 | 12 | 198 | Focal adhesion | 1.10E‐06 | 175 | 1301 | Metabolic pathways | |
| 4.70E‐04 | 9 | 167 | Phagosome | 6.50E‐05 | 13 | 31 | Propanoate metabolism | |
| 6.00E‐03 | 6 | 103 | Amoebiasis | 8.10E‐05 | 13 | 32 | Citrate cycle (TCA cycle) | |
| 1.20E‐02 | 10 | 353 | PI3K‐Akt signaling pathway | 2.60E‐04 | 17 | 57 | Fatty acid metabolism | |
| 1.20E‐02 | 6 | 136 | Apoptosis | 5.40E‐04 | 13 | 38 | Pyruvate metabolism | |
| 1.20E‐02 | 5 | 86 | Gap junction | 2.10E‐03 | 11 | 32 | Beta‐Alanine metabolism | |
| 1.20E‐02 | 6 | 129 | Relaxin signaling pathway | 3.10E‐03 | 20 | 90 | Protein digestion and absorption | |
| 1.20E‐02 | 7 | 171 | Alzheimer disease | 9.10E‐03 | 13 | 50 | Fatt acid degradation | |
| Juvenile‐Aged | 9.20E‐08 | 14 | 90 | Protein digestion and absorption | 9.00E‐05 | 24 | 83 | ECM‐receptor interaction |
| 1.60E‐04 | 10 | 83 | ECM‐receptor interaction | 2.00E‐03 | 18 | 64 | Glutathione metabolism | |
| 2.90E‐03 | 14 | 227 | Thermogenesis | 3.40E‐02 | 13 | 50 | Fatty acid degradation | |
| 6.40E‐03 | 17 | 348 | Human papillomavirus infection | 3.40E‐02 | 14 | 55 | Valine, leucine and isoleucine degradation | |
| 7.50E‐03 | 11 | 171 | Alzheimer disease | 3.40E‐02 | 14 | 58 | Lysine degradation | |
| 1.20E‐02 | 7 | 78 | Cardiac muscle contraction | 3.40E‐02 | 19 | 92 | Small cell lung cancer | |
| 1.20E‐02 | 10 | 159 | Cell adhesion molecules (CAMs) | 3.60E‐02 | 10 | 35 | Fructose and mannose metabolism | |
| 1.30E‐02 | 10 | 167 | Phagosome | 3.60E‐02 | 20 | 101 | AGE‐RAGE signaling pathways in diabetic complications | |
| 1.30E‐02 | 11 | 198 | Focal adhesion | 3.80E‐02 | 15 | 68 | Drug metabolism | |
| 1.30E‐02 | 10 | 166 | Tight junction | 3.80E‐02 | 22 | 119 | Carbon metabolism | |
| Adult‐Aged | NO DEGs | 8.40E‐20 | 48 | 129 | Ribosome | |||
| 3.00E‐04 | 26 | 131 | Oxidative phosphorylation | |||||
| 3.00E‐04 | 37 | 227 | Thermogenesis | |||||
| 5.80E‐04 | 26 | 140 | Parkinson disease | |||||
| 9.10E‐04 | 29 | 171 | Alzheimer disease | |||||
| 3.00E‐03 | 25 | 148 | Non‐alcoholic fatty liver disease (NAFLD) | |||||
| 1.00E‐01 | 25 | 189 | Huntington disease | |||||
| 1.80E‐01 | 12 | 72 | Adherens junction | |||||
| 2.70E‐01 | 27 | 231 | Ras signaling pathway | |||||
| 2.70E‐01 | 12 | 78 | Cardiac muscle contraction | |||||