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(A) Dose-dependent protein tyrosine phosphatases 1B inhibitory activity of Shikonin. Ursolic acid, a strong inhibitor of PTP1B, was used as a positive control. The data shown are mean ± S.E.M. of three independent experiments performed in duplicate (* p < 0.01, ** p < 0.001, and *** p < 0.0001 represent a significant difference compared with the control). (B) IC50 graph of Shikonin against PTP1B. (C) IC50 graph of ursolic acid against PTP1B.
