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Effects of MAN-CS-OVA-PLGA-MPs on the ratio of CD3+ CD4+ T cells to CD3+ CD8+ T cells in spleen cells of mice 28 days following the first immunization. Blood samples were collected and the ratio of CD4+/CD8+ was determined by FACS. Results are presented as the mean ± SD (n = 3). ** p < 0.01 compared with OVA group; ## p < 0.01 compared with OVA group.
