Table 1.

CD47 effect in neurodegenerative diseases.

Neurodegenerative Diseases	CD47 Effect	Therapeutic Strategy	References
Stroke	Stimulation of disease	CD47 blocking antibody	[10,41]
Multiple Sclerosis	Function during initiation and progression has opposing effects	Modulating CD47 could be harmful and beneficial, depending on the context	[42]
Alzheimer’s Disease	Stimulation of disease	Inhibition of CD47	[43]
Spinal Cord Injury	Stimulation of disease	Inhibition of CD47	[7]
Traumatic Brain Injury	Progression of brain tissue damage and promotion of neutrophil infiltration	Inhibition of CD47	[44]
Parkinson’s Disease	Mediation of protective mechanisms	Rac1/Akt activation.	[45]