Figure 4.

a) Representation of intravenous delivery of encapsulated drug in nanocarriers. (Top) Passive targeting of liposomal nanocarriers through the EPR effect, (Bottom) Ligand carrying liposomes for active tumor targeting. Reproduced with permission.^{[ 9 ]} Copyright 2019, John Wiley and Sons. b) An example of drug carrying tumor targeting liposome through a hyaluronic acid conjugate recognized by CD44 receptor. The liposome is endocytosed and acidic pH within a transformed cell causes the release of the docetaxel anticancer drug. Reproduced with permission.^{[ 175 ]} Copyright 2018, Elsevier. c) Presentation of multiple approaches to design stimuli responsive liposomes, while incorporating targeting ligands to achieve selective drug release. Reproduced with permission.^{[ 180 ]} Copyright 2017, John Wiley and Sons.