Table 1.
Summary of the effects of conditions on the yield of the bromomethylation of acridine.
| Experiment No. | BMME (molar eq.) 1 |
Temperature (°C) |
Reaction Time (h) |
Yield (%) |
|---|---|---|---|---|
| 1 | 4 | 50 | 18 | 48 [55] |
| 2 | 4 | 50 | 24 | 49 |
| 3 | 4 | 65 | 24 | 51 |
| 4 | 4 | 65 | 48 | 55 (chrom) 2/79 (cryst) 3 |
| 5 | 6 | 65 | 48 | 37 |
| 6 | 4 | 75 | 48 | 40 |
1 Related to the amount of acridine. 2 Performing the reaction in optimized conditions and then purifying the crude product by column chromatography. 3 Performing the reaction in optimized conditions and then purifying the crude product by recrystallization.