Table 5.
Clinical outcomes.
| Day-28 status |
||||
|---|---|---|---|---|
| Alive (n = 793) | Dead (n = 173) | All (n = 966) | p-value | |
| SOFA score at day 7 (n = 828) | 4 [2–7] | 8 [5–12] | 4 [2–8] | < 0.0001 (a) |
| SOFA score at day 14 (n = 686) | 3 [0–6] | 7 [5–10] | 3 [1–7] | < 0.0001 (a) |
| Overall complications (n = 966) | ||||
| Mechanical ventilation | 576 (73%) | 143 (83%) | 719 (74%) | 0.0062 (b) |
| Vasopressor support | 484 (61%) | 137 (79%) | 621 (64%) | < 0.0001 (b) |
| VAP/HAP | 342 (43%) | 69 (40%) | 411 (43%) | 0.4344 (b) |
| Myocarditis | 15 (2%) | 8 (5%) | 23 (2%) | 0.0488 (d) |
| Cardiac arrest | 18 (2%) | 28 (16%) | 46 (5%) | < 0.0001 (b) |
| Pulmonary embolism | 106 (13%) | 32 (19%) | 138 (14%) | 0.0806 (b) |
| AKI | 201 (25%) | 86 (50%) | 287 (30%) | < 0.0001 (b) |
| AKIN 1 score [32] (n = 287) | 63 (31%) | 7 (8%) | 70 (24%) | |
| AKIN 2 score [32] (n = 287) | 41 (20%) | 20 (24%) | 61 (21%) | |
| AKIN 3 score [32] (n = 287) | 97 (48%) | 58 (68%) | 155 (54%) | |
| RRT | 99 (13%) | 43 (25%) | 142 (15%) | 0.0001 (b) |
| RRT mode (n = 136) | 0.2344 (b) | |||
| CVVH | 19 (20%) | 14 (34%) | 33 (24%) | |
| CVVHD | 12 (13%) | 2 (5%) | 14 (10%) | |
| CVVHD Ci-Ca | 35 (37%) | 13 (32%) | 48 (35%) | |
| CVVHDF | 29 (31%) | 12 (29%) | 41 (30%) | |
| Duration to RRT (days) | 5 [3–10] | 6 [3–9] | 5 [3–9] | |
| ECMO (n = 966) | 43 (5%) | 20 (12%) | 63 (7%) | < 0.0031 (b) |
| Mode (n = 62) | ||||
| VA | 2 (5%) | 6 (30%) | 8 (13%) | |
| VV | 40 (95%) | 14 (70%) | 54 (87%) | |
| Duration to ECMO (days) (n = 63) | 5 [0−18] | 4 [0−15] | 5 [0−18] | 0.1088 (a) |
| Liver dysfunction | 46 (6%) | 15 (9%) | 61 (6%) | 0.1597 (b) |
| No complication | 263 (33%) | 19 (11%) | 282 (29%) | < 0.0001 (b) |
ICU: intensive care unit, LOS: length of stay, SOFA: Sequential Organ Failure Assessment, VAP/HAP: ventilator/healthcare-associated pneumonia, AKI: acute kidney injury, AKIN: acute kidney injury network, RRT: renal replacement therapy. CVVH: continuous veno-venous haemofiltration, CVVHD: continuous veno-venous haemodialysis, CVVHDF: continuous veno-venous haemodiafiltration. ECMO: Extra Corporeal Membrane Oxygenation. VA: venous-arterial. VV: Veno-venous.
For continuous variables median [interquartile-range] are given. For categorical variables, numbers (%) are given.
(a) Wilcoxon test, (b) Chi2 test, (d) Fisher’s exact test.