Table 6.
Independent risk factors associated with 28-day mortality.
| OR | 95% CI | p-value | |
|---|---|---|---|
| Model 1: Multivariate analyses of admission characteristics | |||
| Age | |||
| < 50 years | 1.0 | ref | _ |
| 50–59 years | 2.2 | [0.8–5.7] | 0.1126 |
| 60–69 years | 2.0 | [0.8–5] | 0.1423 |
| 70–79 years | 3.3 | [1.3–8.3] | 0.0113 |
| ≥ 80 years | 9.0 | [3.3–24.6] | < .0001 |
| Gender, female | 1.0 | [0.6–1.5] | 0.8533 |
| Body Mass Index > 40, kg.m−2 | 1.7 | [0.8–3.7] | 0.1793 |
| COPD | 1.3 | [0.8–2] | 0.2497 |
| Chronic heart failure | 2.4 | [1.1–5] | 0.0241 |
| Chronic renal failure | 2.1 | [1.2–3.8] | 0.0113 |
| Cancer | 1.6 | [0.9–2.7] | 0.0956 |
| Arterial hypertension | |||
| No | 1.0 | ref | – |
| Yes, with treatment by ACEI or ARB | 1.1 | [0.7–1.7] | 0.6448 |
| Yes, without treatment by ACEI or ARB | 0.9 | [0.5–1.5] | 0.6103 |
| SOFA score (without respiratory component) at inclusion | |||
| < 2 | 1.0 | ref | – |
| ≥ 2 | 2.4 | [1.6–3.7] | < .0001 |
| PaO2/FiO2 | |||
| > 200 mmHg | 1.0 | ref | – |
| 150−200 mmHg | 1.1 | [0.6–2.1] | 0.8012 |
| 100−150 mmHg | 1.1 | [0.7–1.9] | 0.6798 |
| < 100 mmHg | 1.8 | [1.1–2.9] | 0.0161 |
| Model 2: Multivariate analysis of care at admissiona | |||
|---|---|---|---|
| Respiratory support | |||
| Oxygen therapy or no ventilation | 1.0 | ref | – |
| High-Flow Nasal Cannula or Non-Invasive Ventilation | 0.6 | [0.2–1.5] | 0.2868 |
| Mechanical Ventilation | 1.6 | [0.7–3.4] | 0.2756 |
| Anticoagulants | |||
| No anticoagulants | 1.0 | ref | – |
| Prophylactic dosing | 0.7 | [0.4–1.4] | 0.3762 |
| Therapeutic dosing | 0.9 | [0.5–1.8] | 0.7503 |
| Antiviral therapy on admission | |||
| No antiviral therapy on admission | 1.0 | ref | |
| Antiviral therapy on admission | 0.5 | [0.3−0.9] | 0.0194 |
| Hydroxychloroquine on admission | 1.0 | [0.6–1.6] | 0.9414 |
| Corticosteroids on admission | 1.0 | [0.5–1.9] | 0.9000 |
OR were calculated using random effects logistic regression. The regression was based on 908 patients for 28-day mortality.
OR: odds ratio, CI: Confidence Interval, SOFA: Sequential Organ Failure Assessment. COPD: Chronic Obstructive Pulmonary Disease, ICU: Intensive Care Unit; SOFA: Sequential Organ failure Assessment; PaO2: Oxygen Arterial Pressure; PCO2: carbon dioxide arterial pressure; COPD: chronic obstructive pulmonary disease; ACEI: angiotensin converting enzyme inhibitor, ARB: angiotensin receptor blocker.
Bold values represent statistically significant values.
a
Model 2 was adjusted for characteristics at admission.