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Activation of Nrf2-mediated antioxidant signaling cascade by dietary flavonoids. Nrf2 and Keap1 ubiquitously coupled in the cytosol and lead to the spontaneous destruction of Nrf2. Dietary flavonoids inhibit the Nrf2-Keap1 protein-protein interaction, which results in free Nrf2 to get phosphorylated and bind with the ARE, which activates the downstream antioxidant signaling via up-regulation of HO1 and NQO1.
