Table 3.

Flavonoid-drug interaction [111].

Drugs	Flavonoid	Species in Which Tested	Change in Bioavailability
Diltiazem (15 mg/kg, oral)	Morin (1.5–7.5 mg/kg, oral)	Rat	1.4- to 1.8-fold increases
Talinolol (10 mg/kg, oral)	Naringin (1–20 mg/kg, oral)	Rat	1.5- to 3.0-foldincreases
Etoposide (6 mg/kg, oral)	Morin (15 mg/kg, oral)	Rat	1.4-fold increases
Digoxin (0.02 mg/kg, oral)	Quercetin (40 mg/kg, oral)	Pig	1.7-foldincreases
Moxidectin (0.2 mg/kg, subcutaneous)	Quercetin (10 mg/kg, subcutaneous)	Sheep	1.8-fold increases
Verapamil (10 mg/kg, oral)	Quercetin (15 mg/kg, oral)	Rabbit	2-fold increases
Paclitaxel (30 mg/kg oral)	Genistein (10 mg/kg, oral)	Rat	1.5-fold increases