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. 2021 Jun 29;26(13):3984. doi: 10.3390/molecules26133984

Table 1.

Advantages and drawbacks of emerging extraction technologies.

Emerging Technology Advantages Drawbacks
USAE ↓ Energy, time and solvent consumption Can induce oxidation pyrolysis
↑ Solvent penetration into plant material (mixing effect) and extraction yields Promote free radical formation
Easy to use and low equipment cost High ultrasound waves has deleterious effects on phytochemicals
Facilitate mass transfer ↑ Temperature by cavitation
Compatibility with GRAS solvents Low selective
MWAE ↓ Time and solvent consumption High energy consumption
↑ Extraction yields Excessive temperature (phytochemicals degradation)
Cost-effective equipment Oxidation reactions
Easily to scale up Low selective (large number of compounds extracted)
PEFAE ↓ Energy, time and solvent consumption Very expensive equipment
Very low changes in temperature Need proper solvent and electrical conductivity
Minimize degradation of thermolabile phytochemicals
Easily to scale up
High selectivity
SFAE ↓Extraction time High energy consumption
No use toxic solvents Very expensive and complex equipment
Extracts are pure, and present high quality Need co-solvent to ensure the correct extraction of polar compounds
Effective (low viscosity and high diffusivity) Scale up not feasible
↑ Extraction yields
Continual process
Recycling supercritical fluid
Preserve thermolabile phytochemicals
Tunable supercritical fluid (solvent) density

USAE: ultrasound-assisted extraction; MWAE: microwave-assisted extraction; PEFAE: pulsed electric field-assisted extraction; SFAE: supercritical fluid-assisted extraction. Information was obtained from previous studies [27,28,29,35,40,41].