Table 4.
Activity of isolated compounds against L. mexicana strains (n = 3).
Leish WT | C12Rx | ||||
---|---|---|---|---|---|
Sample | AVG (µM) | SEM (µM) | AVG (µM) | SEM (µM) | RF |
Pinobanksin 3-O-acetate |
163 | 37 | n.t. | n.t. | |
Tectochrysin | >400 | 308 | 33 | ||
Kaempferol | 414 | 130 | n.t. | n.t. | |
Pinostrobin | 25.1 | 2.9 | 6.1 | 1.0 | 0.24 |
4′-methoxykaempferol | 41.4 | 8.6 | 10.4 | 0.9 | 0.25 |
Galangin | 20.2 | 5.0 | 54.4 | 12.7 | 2.6 |
Chrysin | 17.6 | 1.7 | 21.4 | 3.4 | 1.25 |
Apigenin | 24.3 | 3.0 | 10.3 | 0.9 | 0.43 |
Pinocembrin | 60.9 | 7.8 | 31.5 | 4.4 | 0.52 |
Cinnamic acid | 111 | 14 | 34.6 | 6.8 | 0.31 |
Naringenin 4′7- dimethyl ether | 17.8 | 0.9 | 14.0 | 1.7 | 0.79 |
Coumaric acid cinnamyl/benzyl ester | 13.1 | 1.00 | 13.6 | 2.5 | 1.04 |
Kaempferol 4′ 7-dimethyl ether | 12.9 | 3.7 | n.t. | n.t. | |
Miltefosine | 4.91 | 0.14 | 70.5 | 3.8 | 14.4 |
n.t. = not tested.