Table 2.

List of selected miRNAs

Selected miRNA	Function related to hyperuricemia/gout	Reference
miR-17-5p*	suppresses NLRP3 inflammasome activation, miR-17-92 cluster	[17, 18]
miR-18a-5p*	increased by IL-1β in OA, miR-17-92 cluster	[19]
miR-30a-3p	regulates the autoimmune responses occurring in RA	[20]
miR-30c-5p*	inhibits pyroptosis incurred by NLRP3	[21]
miR-126-3p	targets the CCL2 mRNA	[22]
miR-133a-3p*	suppresses NLRP3 inflammasome activation	[23]
miR-142-3p*	inhibits the expression of ABCG2	[24]
miR-143-3p*	targets the GLUT9 mRNA	[25]
miR-146a-5p	increased by MSU crystals, regulates the inflammatory response	[26]
miR-155-5p	increased by MSU crystals, promotes the production of proinflammatory cytokines	[27]
miR-222-3p*	targets the ABCG2 mRNA	[28]
miR-223-3p	reduces NLRP3 inflammasome activity	[14]
miR-488-3p	regulates the production of proinflammatory cytokines, targets the IL1B mRNA, decreased at patients with GA	[29]
miR-920	regulates the production of proinflammatory cytokines, targets the IL1B mRNA, decreased at patients with GA	[29]

OA osteoarthritis, RA rheumatoid arthritis, MSU monosodium urate, GA gouty arthritis

miRNAs signed with a * indicate significant differences in TLDA screening