Figure 6. Percent dead tumor cells model validation shows that low-intensity electric field promotes iontophoretic delivery of carboplatin into breast cancer cells.

(A) Representative of the experimental measurement region in the cell culture chamber of the device, for calculating the percent dead tumor cells when treated with 2 nM of carboplatin with and without 50 mV of electric field. (B) Graph shows increase in percent dead tumor cells that are seeded at 50 μm,150 μm, and 250 μm distance from the bottom of the cell culture chamber and treated with 2 nM of carboplatin with and without 50 mV of electric field; the difference in the percent dead cells when treated with 2 nM of carboplatin with electric field is significantly higher at 250 μm (closest to drug source) compared to other distances. (C) Percent dead tumor cells model validation with the in vitro experiment shows an accurate correlation between model and experiment (Table S3).