Table 4.
Correlation analysis of VTRNA2-1 methylation levels and risk factors of preterm birth
| Variable | Maternal age | Education | Parity | Diagnosisb | WBC |
|---|---|---|---|---|---|
| VTRNA2-1_pos1 | 0.183 | -0.107 | -0.019 | 0.273* | 0.105 |
| VTRNA2-1_pos2 | 0.169 | -0.095 | -0.020 | 0.279* | 0.104 |
| VTRNA2-1_pos3 | 0.174 | -0.147 | -0.009 | 0.293** | 0.094 |
| Hypo vs. Elevateda | 0.179 | -0.128 | -0.011 | 0.246* | 0.075 |
The association between the categorical data for VTRNA2-1 methylation and the categorical data for preterm birth risks were analyzed using Fisher’s exact test. The association between the others and VTRNA2-1 methylation were analyzed using Pearson correlation analysis
VTRNA2-1_pos1, _pos2, and _pos3 were analyzed by pyrosequencing as CpG sites of chromosome 5:135,416,205, chromosome 5:135,416,207, and chromosome 5:135,416,214, respectively
aIt divided two groups as hypomethylation (< 13 %) and elevated methylation (30–60 %)
bDiagnosis were analysed by substituting 1 for PTL, a nominal variable, and 2 for pPROM
*p < 0.05
**p < 0.01