Table 5.
Logistic regression analysis of the association between cg04481923 methylation level in VTRNA2-1 gene and preterm births (n = 82)
| Methylation | β-value | SE | Odds ratio | 95 % CI | p-value |
|---|---|---|---|---|---|
| Age | -0.057 | 0.035 | 0.945 | 0.882–1.012 | 0.104 |
| Season | -0.582 | 0.238 | 0.559 | 0.350–0.892 | 0.015 |
| Parity | 0.389 | 0.313 | 1.475 | 0.798–2.727 | 0.215 |
| VTRNA2-1a | 1.185 | 0.574 | 3.269 | 1.061–10.069 | 0.039 |
| WBC count | 0.211 | 0.075 | 1.235 | 1.066–1.431 | 0.005 |
β-values and SE estimated using the multivariable logistic regression model
VTRNA2-1 vault RNA 2 − 1
aIt was divided into two groups based on the methylation level of VTRNA2-1 promoter: a hypomethylated group (< 13 %, n = 28) and an elevated methylated group (30–60 %, n = 54)