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. 2021 Jul 9;158:25. doi: 10.1186/s41065-021-00190-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — A protein–protein interaction (PPI) network of all common differentially expressed genes (CDEGs) included 96 nodes and 144 edges (A). One significant module was selected using the MCODE plugin, this module consisted of 10 nodes and 25 edges (B). Using miRNet online tools, 1047 predicted differentially expressed microRNAs (DEmiRNAs) of 79 upregulated CDEGs (C), and 832 predicted DEmiRNAs of 89 downregulated CDEGs (D) were identified in EC and HIP samples. The DEmiRNAs from EC and HIP were intersected with the DEmiRNAs from blood samples, 55 common DEmiRNAs (CDEmiRNAs) were further identified, including 30 downregulated CDEmiRNAs (C) and 25 upregulated CDEmiRNAs (D)