Table 1.
Deposition following administration of one single dose of four puffs of the beclomethasone/formoterol hydrofluoroalkane (100/6 μg) radiolabelled formulation in healthy subjects, asthmatic, and chronic obstructive pulmonary disease patients
Healthy subjects (n=8) | Asthma patients (n=8) | COPD patients (n=8) | |
---|---|---|---|
Lung deposition (percentage nominal dose) | 34.08±9.30 (20.00-43.80) | 30.86±8.89 (21.50-47.40) | 33.10±8.90 (14.00-43.60) |
C/P | 1.42±0.32 (1.14-2.09) | 1.96±0.43* (1.44-2.78) | 1.94±0.69 (1.15-3.07) |
*P=0.046 versus healthy subjects. C/P: Central/peripheral