Table 6.
Distribution of adverse drug reactions experienced after the start of therapy
| Frequency, n (%) | |||
|---|---|---|---|
| After 6 months of therapy | After 12 months of therapy | After 24 months of therapy | |
| Gastrointestinal symptoms | |||
| Nausea and vomiting | 20 (30.76) | 57 (39.86) | 6 (21.42) |
| Severe gastritis | 8 (12.30) | 6 (4.19) | 5 (17.85) |
| Musculoskeletal disorders | |||
| Arthralgia | 3 (4.61) | 25 (17.48) | 5 (17.85) |
| Skin and subcutaneous tissue disorders | |||
| Acne vulgaris | 4 (6.15) | 7 (4.89) | 2 (7.14) |
| Dermatitis | 3 (4.61) | 4 (2.79) | 0 |
| Central nervous systems disorders | |||
| Peripheral neuropathy | 5 (7.69) | 13 (9.09) | 3 (10.71) |
| Giddiness | 7 (10.76) | 14 (9.79) | 0 |
| Endocrine disorders | |||
| Hypothyroidism | 4 (6.15) | 3 (2.09) | 0 |
| Gynaecomastia | 2 (3.07) | 1 (0.69) | 0 |
| Psychiatric disorders | |||
| Psychosis | 2 (3.07) | 2 (1.39) | 0 |
| Renal toxicity | |||
| Nephrotoxicity | 0 | 3 (2.09) | 0 |
| Vestibular toxicities | |||
| Ototoxicity | 0 | 3 (2.09) | 3 (10.71) |
| Tinnitus and mild hearing loss | 7 (10.76) | 5 (3.49) | 4 (14.28) |
| Total (n) | 65 | 143 | 28 |
ADRs: Adverse drug reaction