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. Author manuscript; available in PMC: 2022 Aug 15.
Published in final edited form as: Bioorg Med Chem Lett. 2021 Jun 15;46:128171. doi: 10.1016/j.bmcl.2021.128171

Table 3.

Modification of the piperidine amide of 2.

graphic file with name nihms-1715713-t0013.jpg
No R IC50 (μM)a CC50 (μM)b
224 graphic file with name nihms-1715713-t0025.jpg 0.53 ± 0.08 65.0
17 graphic file with name nihms-1715713-t0026.jpg >50 >50
18 graphic file with name nihms-1715713-t0027.jpg >50 >50
19 graphic file with name nihms-1715713-t0028.jpg 17.6c 66.7c
20 graphic file with name nihms-1715713-t0029.jpg 24.7 ± 3.5 77.3
21 graphic file with name nihms-1715713-t0030.jpg 24.4 ± 4.0 78.0
22 graphic file with name nihms-1715713-t0031.jpg 3.9 ± 0.4 74.2
23 graphic file with name nihms-1715713-t0032.jpg >50 >50
2424 graphic file with name nihms-1715713-t0033.jpg 1.6 ± 0.8 47.9
25 graphic file with name nihms-1715713-t0034.jpg 24.4 ± 6.3 61.0
26 graphic file with name nihms-1715713-t0035.jpg 24.6 ± 1.6 >100
27 graphic file with name nihms-1715713-t0036.jpg 0.96 ± 0.06 50.9
28 graphic file with name nihms-1715713-t0037.jpg 10.9 ± 0.6 56.5
29 graphic file with name nihms-1715713-t0038.jpg 0.49 ± 0.09 41.1
a

Inhibition of luciferase expression in WEEV replicon assay.

b

Cell viability determined by the MTT reduction assay. Values are mean of at least n=3 independent experiments.

c

Value is n=1 experiment.