Table 2.
Herbal mixture sample/case number (n) | Ingredients | Control sample number (n) | Total clinical effect rate | Model used | Therapeutic effects and actions | Refs. |
---|---|---|---|---|---|---|
Shaofu Zhuyu decoction (SZD); n = 20 | Xiao Hui Xiang, Gan Jiang, Yuan Hu, Mo Yao, Dang Gui, Chuan Xiong, Guan Gui, Mu Dan Gen, Pu Huang, Wu Ling Zhi | Ibuprofen; n = 20 | T: 90.00% versus 70.00% | Human study | Alleviating dysmenorrhea. CA-125↓, PEG2↓ |
[23] |
Wengjing decoction (WJD); n = 48 | Wu Zhu Yu, Mai Dong, Dang Gui, Mu Dan Pi, Chuan Xiong, Ren Sheng, Gui Zhi, E Jiao, Bai Shao, Sheng Jiang, Ban Xia, Gan Cao | Mifepristone; n = 48 | T: 93.75% versus 79.17% | Human study | Alleviating dysmenorrhea. CD4+↓, CD4+/CD8+↓, IL-4↓, IL-10↓ |
[26] |
Xuefu Zhuyu decoction (XZD); n = 60 | Dang Gui, Sheng Di Huang, Tao Ren, Hong Hua, Zhi Qiao, Chi Shao, Chai Hu , Gan Cao, Jie Geng, Chuan Xiong, Niu Xi | Mifepristone; n = 60 | T: 90.0% versus 73.3% | Human study | Alleviating dysmenorrhea. Reducing VAS scores. |
[30] |
Danggui Sini decoction (DSD); n = 37 | Dang Gui, Gui Zhi, Shao Yao, Xi Xin, Tong Cao, Zhi Gan Cao, Da Zao | Progesterone; n = 37 | D: 89.19% versus 67.57% | Human study | Alleviating dysmenorrhea. | [34] |
Danggui Shaoyao Powder (DSP); n = 40 | Dang Gui, Shao Yao, Chuan Xiong, Fu Ling, Ze Xie, Bai Zhu | Progesterone; n = 40 | T: 97.5% versus 82.5% | Human study | Alleviating dysmenorrhea. Reducing VAS scores. PEG2↓, P↓ |
[35] |
Note: T (Total effect rate) = number of effective cases/total number of cases; where effective case refers to the patients or animal models whose signs and symptoms were improved after treatment. D: dysmenorrhea alleviation rate.