Table 3.

Comparison of patient reported outcomes between breast cancer survivors and controls, by chemotherapy and stage at diagnosis

	Women with no history of cancer	Women with a history of breast cancer
		All		Treated with chemotherapy				Stage of disease at diagnosis
				No chemotherapy		Chemotherapy		Localised		Advanced
		β*	95%CI	β*	95%CI	β*	95%CI	β*	95%CI	β*	95%CI
QLACS:
Generic domains
Negative feelings	Ref.	0.7	− 0.1–1.4	0.1	− 0.7–1.0	1.4	0.2–2.6	0.2	− 0.6–1.0	1.4	0.2–2.5
Positive feelings	Ref.	− 0.3	− 1.2–0.6	− 0.2	− 1.2–0.8	− 0.6	− 1.9–0.7	− 0.2	− 1.2–0.7	− 0.5	− 1.8–0.8
Cognitive problems	Ref.	1.4	0.4–2.3	0.6	− 0.3–1.5	2.6	1.3–3.8	0.9	− 0.1–1.9	2.0	0.9–3.2
Pain	Ref.	0.2	− 1.1–1.6	− 0.2	− 1.6–1.2	0.9	− 0.8–2.6	− 0.6	− 2.0–0.8	1.2	− 0.4–2.8
Sexual function	Ref.	1.7	0.4–3.0	1.2	0.0–2.4	2.5	0.6–4.3	0.8	− 0.5–2.1	2.9	1.3–4.6
Energy/Fatigue	Ref.	1.3	0.4–2.2	1.2	0.2–2.1	1.5	0.4–2.7	1.0	0.0–2.0	1.7	0.6–2.9
Avoidance	Ref.	0.1	− 1.0–1.2	− 0.3	− 1.5–0.9	0.8	− 0.6–2.2	− 0.2	− 1.2–0.8	0.6	− 0.9–2.2
Summary	Ref.	5.9	− 0.2–11.8	2.3	− 3.6–8.2	11.0	3.6–18.3	1.8	− 4.1–7.7	11.1	3.8–18.3
HADS
Anxiety	Ref.	0.5	− 0.1–1.0	0.1	− 0.6–0.8	1.1	0.2–2.0	0.4	− 0.3–1.0	0.8	− 0.2–1.7
Depression	Ref.	0.1	− 0.5–0.7	0.1	− 0.6–0.7	0.2	− 0.7–1.0	0.0	− 0.7–0.7	0.3	− 0.5–1.0

*Beta scores represent the difference between the scores of breast cancer survivors and the scores of the women in the comparison group. These were adjusted for adjusted for age, education, and IMD quintile. Positive beta scores indicate more problems (poorer QoL) in breast cancer survivors

HADS Hospital Anxiety and Depression Scale, QLACS Quality of Life in Adult Cancer Survivors, 95%CI 95% confidence interval