Fig. 1.

Disposition of subjects in the study. a We made three types of comparisons: controls (n = 79) with symptom-free patients (n = 77), symptom-free samples with the patients’ own attack samples (n = 14), and symptom-free samples with the patients’ own EM (prodromal) samples (n = 8). b A 56-year-old female patient with type I C1-INH-HAE was followed from her symptom-free phase (green), during EM (prodrome) (yellow) and angioedema attack (orange) until remission. Twelve EDTA-plasma samples were collected from the patient (solid circles) and 5 from the control person (open circles). Circles indicate sampling times. Normal range is represented by dotted lines