Table 3.
Factors related to neutrophil activation in healthy controls and C1-INH-HAE patients during symptom-free periods
| Healthy controls (n = 79) | C1-INH-HAE symptom-free period (n = 77) | P value | |
|---|---|---|---|
| PRTN3 (ng/ml) | 19.7 (14.6–28.69) | 23.2 (16.2–27.8) | ns |
| CCL5 (ng/ml) | 12.4 (5.1–24.7) | 19.2 (10.2–28.7) | 0.0076 |
| TNF a (pg/ml) | 12.4 (8.1–14.8) | 9.9 (8.1–14.1) | ns |
| IL-8 (pg/ml) | 0.94 (0.41–1.66) | 1.01 (0.6–1.43) | ns |
| MCP-1 (pg/ml) | 54 (44.6–73.7) | 64.5 (52–83.2) | 0.0288 |
| NE (ng/ml) | 31.6 (24.5–40.9) | 29.9 (22.6–37.6) | ns |
| NET (activated cells/100 µl) | 159.3 (132.4–191.4) | 158.7 (139.2–190.9) | ns |
| MPO (ng/ml) | 72.6 (54.6–90.1) | 77.4 (64.4–102.1) | 0.0478 |
| LTB4 (ng/ml) | 61.5 (45.1–110.3) | 63 (41–158.1) | ns |
Ns: non-significant
Values are medians (25–75% percentile). P values were calculated with Mann–Whitney test