Table 3.
Associations between sarcopenia at baseline, individual characteristics, physical condition and oxidative stress enzymes at 6 months from the ABLE study (n = 49)
| Month 6 | All patients (n = 47) Mean (SD) or n (%) |
Nonsarcopenic (n = 22) Mean (SD) or n (%) |
Sarcopenic (n = 25) Mean (SD) or n (%) |
p value |
|---|---|---|---|---|
| Anthropometrics | ||||
| Weight (kg), mean (SD) | 67.37 (15.59) | 75.21 (17.26) | 61.17 (10.96) | < 0.01 |
| BMI (kg/m2), mean (SD) | 25.41 (5.91) | 28.68 (6.55) | 22.81 (3.77) | < 0.01 |
| Underweight (< 18.5 kg/m2), n (%) | 3.0 (7.0) | 1.0 (5.3) | 2.0 (8.3) | 0.02 |
| Normal weight (< 25 kg/m2), n (%) | 21.0 (48.8) | 5.0 (26.3) | 16.0 (66.7) | |
| Overweight (25–30 kg/m2), n (%) | 11.0 (25.6) | 6.0 (31.6) | 5.0 (20.8) | |
| Obese (> 30 kg/m2), n (%) | 8.0 (18.6) | 7.0 (36.8) | 1.0 (4.2) | |
| Muscle characteristics | ||||
| Cross-sectional area at L3 (cm2), mean (SD) | 110.19 (16.88) | 121.03 (18.65) | 102.06 (9.50) | < 0.01 |
| SMG (arbitrary units), mean (SD) | 1721.00 (619.03) | 1328.11 (321.71) | 1496.49 (505.64) | 0.04 |
| Low SMD (< 37.8HU) | 26.0 (61.9) | 12.0 (66.7) | 14.0 (58.3) | 0.58 |
| SMI (cm2/m2), mean (SD) | 41.46 (6.19) | 45.96 (6.66) | 38.08 (2.78) | < 0.01 |
| LBM (kg), mean (SD) | 39.12 (5.07) | 42.37 (5.59) | 36.68 (2.85) | < 0.01 |
| SMD (HU), mean (SD) | 35.99 (10.36) | 37.61 (13.29) | 34.78 (7.56) | 0.84 |
| Physical fitness | ||||
| 6 min walking distance (m), mean (SD) | 481.44 (107.23) | 450.00 (114.38) | 506.33 (96.42) | 0.10 |
| Handgrip strength right (kg), mean (SD) | 26.21 (4.34) | 25.67 (4.75) | 26.66 (4.02) | 0.65 |
| Handgrip strength left (kg), mean (SD) | 24.04 (4.44) | 24.13 (4.39) | 23.98 (4.57) | 0.87 |
| Isometric quadriceps strength (N), mean (SD) | 239.19 (77.28) | 259.60 (81.57) | 223.87 (71.83) | 0.16 |
| Physical activity level | ||||
| Total physical activity (MET-minutes/week) | 1910.19 (1771.40) | 2140.32 (2275.71) | 1728.00 (1264.36) | 0.74 |
| Sitting time (min/week) | 1728.60 (846.98) | 1554.74 (897.94) | 1866.25 (796.38) | 0.18 |
| Mean steps per day over a month, mean (SD) | 5266.91 (2736.79) | 4475.36 (2889.51) | 6011.90 (2436.46) | 0.08 |
| Antioxidant enzymes | ||||
| CAT (µmol/min/L), mean (SD) | 37.83 (18.92) | 35.51 (14.89) | 39.67 (21.73) | 0.73 |
| GPx (mol/min/L), mean (SD) | 82.05 (25.63) | 82.59 (24.87) | 81.64 (26.70) | 0.94 |
| SOD (mol/min/L), mean (SD) | 8.88 (4.57) | 10.52 (4.74) | 7.57 (4.07) | 0.06 |
| Pro-oxidant enzymes | ||||
| NADPH oxidase leucocytes, mean (SD) | 0.22 (0.06) | 0.22 (0.06) | 0.22 (0.06) | 0.66 |
| MPO Plasma, mean (SD) | 119.27 (49.38) | 131.87 (52.10) | 109.30 (45.76) | 0.08 |
| MPO Leuco, mean (SD) | 15.73 (7.95) | 15.51 (6.67) | 15.91 (8.97) | 0.92 |
| End products of OS damage lipids | ||||
| MDA (µmol/L), mean (SD) | 12.53 (3.54) | 11.21 (2.22) | 13.57 (4.05) | 0.02 |
| DNA | ||||
| 8-OHdG (µg/L), mean (SD) | 18.00 (15.49) | 16.77 (15.20) | 18.97 (15.98) | 0.66 |
| Protein | ||||
| AOPP (µmol/L), mean (SD) | 88.23 (56.25) | 86.65 (53.01) | 89.49 (59.79) | 0.85 |
| Inflammation | ||||
| IL6 (µmol/L), mean (SD) | 24.41 (9.41) | 35.55 (13.28) | 33.50 (4.64) | 0.79 |
SMD skeletal muscle density, SMI Skeletal Muscle Index, LBM lean body mass, SMG skeletal muscle gauge, BMI Body Mass Index, CAT catalase, GPx glutathione peroxidase, SOD superoxide dismutase, MPO myeloperoxidase, MDA malondialdehyde, 8-OHdG 8-hydroxydésoxyguanosine, AOPP advanced oxidative protein products, IL interleukin