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. 2021 Mar 24;58(8):1059–1070. doi: 10.1007/s00592-021-01681-2

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© The Author(s) 2021, corrected publication 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Effect of empagliflozin administration on glomerular, tubulo-interstitial and perivascular fibrosis in CsA-treated rats.On the left. Representative photomicrographs of glomerular, tubulo-interstitial and perivascular fibrosis in control, control + Empa, CsA, and CsA + empagliflozin-treated rats (original magnification X20). Sirius red, collagen-specific staining, shows an increase in glomerular and tubulo-interstitial fibrosis in CsA-treated rats, as compared to control and control + Empa-treated rats. Empagliflozin administration prevented the increase in glomerular and tubulo-interstitial fibrosis in CsA-treated rats. Perivascular fibrosis did not change among the different experimental groups.On the right. Quantification of glomerular, tubulo-interstitial and perivascular fibrosis in the different groups of rats. Data are means ± SEM. *: p < 0.05. §: p < 0.01