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. 2021 Mar 24;58(8):1059–1070. doi: 10.1007/s00592-021-01681-2

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© The Author(s) 2021, corrected publication 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Effect of empagliflozin administration on type I and type IV collagen expression in CsA-treated rats. On the left. Representative photomicrographs of type I and type IV collagen expression in control, control + Empa, CsA, and CsA + empagliflozin-treated rats (original magnification X20). Type I collagen showed an increased tubulo-interstitial staining in CsA-treated rats, while type IV collagen was increased mainly in the intraglomerular area in CsA-treated rats, as compared to control and control + Empa-treated rats. Empagliflozin administration prevented the increase of both type I and type IV collagen in CsA-treated rats. On the right. Quantification of type I and type IV collagen proteins in renal tubulo-interstitial and glomerular area, respectively, in the different groups of rats. Data are means ± SEM. §: p < 0.01.