Table 1.
Gamma counts representing [125I] oxytocin (OT) concentration 30 min after 0.4 mg [125I] OT intranasal administration (A) without and (B) with Avicel™ mucoadhesive.
| A | B | |
|---|---|---|
| Tissue description | Mean (±SD) [125I] OT concentration (nM) after IN OT (0.4 mg) | Mean (±SD) [125I] OT concentration (nM) after IN OT (0.4 mg) with 1% Avicel |
| Blood | 61 (±4) | 74 (±6) |
| Extra-olfactory nasal epithelium | 680,567 (±85,021) | 817642 (±41,406) |
| Olfactory epithelium | 4112 (±694) | 3153 (±432) |
| Trigeminal ganglion | 311 (±79) | 150 (±38) |
| Maxillary nerve | 264 (±46) | 340 (±50) |
| Mandibular nerve | 291 (±38) | 477 (±117) |
| Ophthalmic nerve | 320 (±58) | 278 (±51) |
| Olfactory bulbs | 33 (±13) | 60 (±15) |
| Anterior olfactory nucleus | 24 (±5) | 39 (±9) |
| Frontal cortex | 21 (±4) | 38 (±10) |
| Caudate/putamen | 41 ± (10.8) | 39 (±12.0) |
| Septal nucleus | 28 (±6) | 40 (±13) |
| Parietal cortex | 28 (±7) | 29 (±4) |
| Hippocampus | 16 (±3) | 21 (±5) |
| Thalamus | 15 (±6) | 10 (±1) |
| Hypothalamus | 21 (±4) | 30 (±4) |
| Midbrain | 14 (±3) | 17 (±4) |
| Pons | 26 (±10) | 27 (±6) |
| Medulla | 25 (±9) | 27 (±7) |
| Cerebellum | 10 (±1) | 16 (±2) |
| Dorsal dura | 152 (±12) | 395 (±78) |
| Ventral dura | 271 (±43) | 992 (±235) |
| Spinal dura | 31 (±8) | 15 (±2) |
| Upper cervical spinal cord | 33 (±8) | 50 (±15) |
| Lower cervical spinal cord | 4 ± (0.3) | 4 (±0.4) |
| Thoracic spinal cord | 5 ± (0.5) | 5 (±0.2) |
| Lumbar spinal cord | 5 ± (0.6) | 4 (±0.3) |
| Superficial nodes (2) | 232 (±25) | 365 (±44) |
| Cervical nodes (2) | 213 (±36) | 398 (±80) |
| Axillary nodes (2) | 22 (±2) | 19 (±2) |
| Thyroid | 213 (±36) | 739 (±110) |
| Muscle | 14 (±1) | 13 (±1) |
| Liver | 13 (±1) | 13 (±1) |
| Kidney | 44 (±3) | 53 (±6) |
| Lung | 21 (±2) | 21 (±2) |
| Trachea | 26 (±3) | 24 (±2) |
| Esophagus | 25 (±2) | 25 (±2) |
| Spleen | 23 (±2) | 22 (±2) |
| Heart | 16 (±1) | 14 (±1) |
| Urine | 73 (±11) | 72 (±12) |
| Drug standard | 8,788,619 (±122,341) | 9,160,899 (±78,596) |
| CPM/fmol | 0.17 (±0.0) | 0.17 (±0.0) |
CPM counts per minute.