Table 2.
Gamma counts representing [125I] oxytocin (OT) concentration 30 min after: (A) 0.4 mg, (B) 0.04 mg, and (C)0.004 mg [I125] OT intranasal administration.
| A | B | C | |
|---|---|---|---|
| Tissue description | Mean (±SD) [125I] OT concentration (nM) IN OT (0.4 mg) | Mean (±SD) [125I] OT concentration (nM) after IN OT (0.04 mg) | Mean (±SD) [125I] OT concentration (nM) after IN OT (0.004 mg) |
| Blood | 61 (±4) | 8.46 (±0.4) | 2.42 (±0.2) |
| Extra-olfactory epithelium | 680,567 (±85,021) | 58,080 (±10,300) | 2728 (±233) |
| Olfactory epithelium | 4112 (±694) | 92 (±27) | 92 (±36) |
| Trigeminal Ganglion | 311 (±79) | 5.3 (±1) | 1.3 (±0.2) |
| Maxillary nerve | 264 (±46) | 7.5 (±0.9) | 1.8 (±0.4) |
| Mandibular nerve | 291 (±38) | 8.9 (±1.2) | 2.6 (±0.3) |
| Ophthalmic nerve | 320 (±58) | 9.3 (±1.2) | 2.1 (±0.3) |
| Olfactory bulbs | 33 (±13) | 3.6 (±0.4) | 0.6 (±0.0) |
| Anterior olfactory nucleus | 24 (±5) | 1.5 (±0.1) | 0.3 (±0.0) |
| Frontal cortex | 21 (±4) | 3.0 (±0.7) | 0.3 (±0.0) |
| Caudate/putamen | 41 ± (10.8) | 1.1 (±0.1) | 0.3 (±0.0) |
| Septal nucleus | 28 (±6) | 1.6 (±0.3) | 0.2 (±0.0) |
| Parietal cortex | 28 (±7) | 1.2 (±0.1) | 0.3 (±0.0) |
| Hippocampus | 16 (±3) | 1.1 (±0.1) | 0.2 (±0.0) |
| Thalamus | 15 (±6) | 1.0 (±0.1) | 0.2 (±0.0) |
| Hypothalamus | 21 (±4) | 1.4 (±0.2) | 0.2 (±0.0) |
| Midbrain | 14 (±3) | 1.1 (±0.1) | 0.2 (±0.0) |
| Pons | 26 (±10) | 1.1 (±0.1) | 0.2 (±0.0) |
| Medulla | 25 (±9) | 1.1 (±0.1) | 0.3 (±0.0) |
| Cerebellum | 10 (±1) | 1.1 (±0.0) | 0.3 (±0.0) |
| Dorsal dura | 152 (±12) | 25 (±4.8) | 4.0 (±0.7) |
| Ventral dura | 271 (±43) | 14 (±1.3) | 2.9 (±0.6) |
| Spinal dura | 31 (±8) | 2.8 (±0.6) | 1.0 (±0.3) |
| Upper cervical spinal cord | 33 (±8) | 1.8 (±0.1) | 0.4 (±0.1) |
| Lower cervical spinal cord | 4 ± (0.3) | 0.7 (±0.1) | 0.2 (±0.0) |
| Thoracic spinal cord | 5 ± (0.5) | 0.6 (±0.0) | 0.1 (±0.0) |
| Lumbar spinal cord | 5 ± (0.6) | 0.7 (±0.0) | 0.1 (±0.0) |
| Circle of Willis/basilar artery | Not tested | 7 (±1.7) | 1.2 (±0.2) |
| Renal artery | Not tested | 2.0 (±0.2) | 0.6 (±0.1) |
| Superficial nodes (2) | 232 (±25) | 32 (±7) | 3.8 (±0.7) |
| Cervical nodes (2) | 213 (±36) | 13 (±2.2) | 3.0 (±0.5) |
| Axillary nodes (2) | 22 (±2) | 1.6 (±0.1) | 0.6 (±0.1) |
| Thyroid | 213 (±36) | 80 (±10) | 29 (±5) |
| Muscle | 14 (±1) | 1.4 (±0.1) | 0.3 (±0.0) |
| Liver | 13 (±1) | 1.1 (±0.1) | 0.6 (±0.1) |
| Kidney | 44 (±3) | 2.2 (±0.3) | 0.6 (±0.1) |
| Lung | 21 (±2) | 2.1 (±0.2) | 0.6 (±0.1) |
| Trachea | 26 (±3) | 3.1 (±0.5) | 0.7 (±0.1) |
| Esophagus | 25 (±2) | 2.3 (±0.2) | 0.9 (±0.1) |
| Spleen | 23 (±2) | 1.9 (±0.2) | 0.6 (±0.1) |
| Heart | 16 (±1) | 1.1 (±0.1) | 0.3 (±0.0) |
| Urine | 73 (±11) | 4.2 (±0.6) | 1.1 (±0.2) |
| CPM/fmol | 0.17 (±0.0) | 1.4 (±0.0) | 12.7 (±0.1) |
CPM counts per minute.