Table 3.
Gamma Counts representing [125I]oxytocin (OT) concentration 60 min after intranasal administration of [125I]OT: (A) 0.4 mg and (B) 0.4 mg with Avicel®™ mucoadhesive (one rat per condition; CPM = counts per minute).
| A | B | |
|---|---|---|
| Tissue description | [125I] OT concentration (nM) after IN OT (0.4 mg) | [125I] OT concentration (nM) after IN OT (0.4 mg) + Avicel™ |
| Blood | 155 | 103 |
| Extra-olfactory epithelium | 1,075,273 | 1,078,689 |
| Olfactory epithelium | 100,193 | 9839 |
| Trigeminal ganglion | 301 | 1106 |
| Maxillary nerve | 163 | 538 |
| Mandibular nerve | 201 | 346 |
| Ophthalmic nerve | 209 | 462 |
| Olfactory bulbs | 80 | 17 |
| Anterior olfactory nucleus | 42 | 12 |
| Frontal cortex | 25 | 66 |
| Caudate/putamen | 31 | 24 |
| Septal nucleus | 24 | 15 |
| Parietal cortex | 14 | 12 |
| Hippocampus | 16 | 13 |
| Thalamus | 11 | 7 |
| Hypothalamus | 26 | 23 |
| Midbrain | 20 | 12 |
| Pons | 42 | 16 |
| Medulla | 37 | 12 |
| Cerebellum | 27 | 14 |
| Dorsal dura | 364 | 232 |
| Ventral dura | 565 | 7168 |
| Spinal dura | 26 | 10 |
| Upper cervical spinal cord | 18 | 26 |
| Lower cervical spinal cord | 10 | 5 |
| Thoracic spinal cord | 11 | 7 |
| Lumbar spinal cord | 18 | 6 |
| Superficial nodes (2) | 109 | 192 |
| Cervical nodes (2) | 381 | 446 |
| Axillary nodes (2) | 51 | 30 |
| Thyroid | 2882 | 3925 |
| Muscle | 36 | 28 |
| Liver | 22 | 39 |
| Kidney | 166 | 56 |
| Lung | 56 | 22 |
| Trachea | 105 | 79 |
| Esophagus | 59 | 126 |
| Spleen | 68 | 48 |
| Heart | 35 | 30 |
| Urine | 676 | 103 |
| Drug standard | 3,995,562 | 4,029,771 |
| CPM/fmol | 0.17 | 0.16 |